Cellular pharmacology of detorubicin and doxorubicin in L1210 cells.

@article{Zenebergh1984CellularPO,
  title={Cellular pharmacology of detorubicin and doxorubicin in L1210 cells.},
  author={A. Zenebergh and Roger Baurain and Andr{\'e} Trouet},
  journal={European journal of cancer & clinical oncology},
  year={1984},
  volume={20 1},
  pages={115-21}
}
Detorubicin (DET), a semi-synthetic analog of daunorubicin, releases at neutral pH doxorubicin (DOX) upon hydrolysis. DET enters faster than DOX into the cultured L1210 cells and reaches higher intracellular levels. When the cells are incubated for 120 min at pH 6.5, in spite of its rapid hydrolysis, one third of the intracellular fluorescence was due to… CONTINUE READING