Cellular pharmacology of cyclopentenyl cytosine in Molt-4 lymphoblasts.

  title={Cellular pharmacology of cyclopentenyl cytosine in Molt-4 lymphoblasts.},
  author={Harry Ford and David A. Cooney and Gurpreet S. Ahluwalia and Zhang Hao and Michel Rommel and Lesley Hicks and K A Dobyns and Joseph E. Tomaszewski and David G. Johns},
  journal={Cancer research},
  volume={51 14},
The toxicity, uptake, and metabolism of the oncolytic nucleoside cyclopentenyl cytosine (CPEC) have been examined in the Molt-4 line of human lymphoblasts. This compound is known to be converted to its 5'-triphosphate, which inhibits CTP synthetase and depletes the pools of cytidine nucleotides. In the Molt-4 system, the concentration of drug reducing proliferation by 50% in a 24-h incubation was between 50 and 100 nM. Cytidine, uridine, and nitrobenzylthioinosine almost fully prevented the… CONTINUE READING


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