Cellular pharmacology of N,N-dimethyl daunorubicin and N,N-dimethyl adriamycin.

Abstract

animal tumors (17)@and are less cardiotoxic in rabbits than are DNA and ADA.3 Although pharmacological studies of N-acet ylated, N-formylated, and N-trifluoroacetylated anthracycline antibiotics have been described, N-alkylated compounds have not been investigated. Since the cellular pharmacology of these compounds was undefined, we compared them to each… (More)

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3 Figures and Tables