Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug

@article{Takemura1996CellularPO,
  title={Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug},
  author={Yuzuru Takemura and William Gibson and Rosemary Kimbell and Hiroyuki Kobayashi and Hayato Miyachi and Ann L. Jackman},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={1996},
  volume={122},
  pages={109-117}
}
We have analysed the cellular metabolism of a novel thymidylate synthase (TS) inhibitor, ZD1694, in MOLT-3 and K562 human leukaemia cell lines sensitive to or made resistant to ZD1694 by continuous exposure of the cells to ZD1694 with stepwise escalation of the drug concentration. The initial cellular uptake of [3H]ZD1694 was greater in K562 cells than in MOLT-3 cells and the drug accumulated approximately 3-fold more in the former cells following incubation with 0.1 μM ZD1694 at 37°C for 24 h… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-6 of 6 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Isolation and characterization of cDNA and genomic clones encoding a human reduced folate carrier

JA Moscow, R He, +3 authors KH Cowan
Proc Am Assoc Cancer Res • 1995
View 1 Excerpt

Mutation in a putative reduced folate carrier contributes to methotrexate resistance in the methotrexate resistant cell line DC-3F/A55

SE Lefebvre, SL Rollins, PW Melera
Proc Am Assoc Cancer Res • 1995
View 1 Excerpt

Folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts

SB Gates, RM Schultz, TD Self, GB Grindey, LG Mendelsohn
Proc Am Assoc Cancer Res • 1994
View 1 Excerpt

Human lymphoblastoid cells

BM O'Connor, AL Jackman, +3 authors AH Calvert
1992

Similar Papers

Loading similar papers…