Cellular peptide composition governed by major histocompatibility complex class I molecules

@article{Falk1990CellularPC,
  title={Cellular peptide composition governed by major histocompatibility complex class I molecules},
  author={Kirsten Falk and Olaf Roetzschke and Hans-Georg Rammensee},
  journal={Nature},
  year={1990},
  volume={348},
  pages={248-251}
}
MAJOR histocompatibility complex (MHC) class I molecules present peptides derived from cellular proteins to cytotoxic T lymphocytes (CTLs)1–5, which check these peptides for abnormal features. How such peptides arise in the cell is not known. Here we show that the MHC molecules themselves are substantially involved in determining which peptides occur intracellularly: normal mouse spleen cells identical at all genes but MHC class I express different patterns of peptides derived from cellular non… CONTINUE READING

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