Cellular pathways of hereditary spastic paraplegia.

@article{Blackstone2012CellularPO,
  title={Cellular pathways of hereditary spastic paraplegia.},
  author={Craig Blackstone},
  journal={Annual review of neuroscience},
  year={2012},
  volume={35},
  pages={
          25-47
        }
}
Human voluntary movement is controlled by the pyramidal motor system, a long CNS pathway comprising corticospinal and lower motor neurons. Hereditary spastic paraplegias (HSPs) are a large, genetically diverse group of inherited neurologic disorders characterized by a length-dependent distal axonopathy of the corticospinal tracts, resulting in lower limb spasticity and weakness. A range of studies are converging on alterations in the shaping of organelles, particularly the endoplasmic reticulum… CONTINUE READING

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