Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinks.

@article{Graaf2009CellularPF,
  title={Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinks.},
  author={Bendert de Graaf and Adam J. Clore and Amanda K. McCullough},
  journal={DNA repair},
  year={2009},
  volume={8 10},
  pages={1207-14}
}
Although it is well established that DNA-protein crosslinks are formed as a consequence of cellular exposure to agents such as formaldehyde, transplatin, ionizing and ultraviolet radiation, the biochemical pathways that promote cellular survival via repair or tolerance of these lesions are poorly understood. To investigate the mechanisms that function to limit DNA-protein crosslink-induced cytotoxicity, the Saccharomyces cerevisiae non-essential gene deletion library was screened for increased… CONTINUE READING

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