Cellular oxygen sensing need in CNS function: physiological and pathological implications.

@article{Acker2004CellularOS,
  title={Cellular oxygen sensing need in CNS function: physiological and pathological implications.},
  author={Till Acker and Helmut Acker},
  journal={The Journal of experimental biology},
  year={2004},
  volume={207 Pt 18},
  pages={3171-88}
}
Structural and functional integrity of brain function profoundly depends on a regular oxygen and glucose supply. Any disturbance of this supply becomes life threatening and may result in severe loss of brain function. In particular, reductions in oxygen availability (hypoxia) caused by systemic or local blood circulation irregularities cannot be tolerated for longer periods due to an insufficient energy supply to the brain by anaerobic glycolysis. Hypoxia has been implicated in central nervous… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 105 references

Widespread hypoxiainducible expression of HIF2 alpha in distinct cell populations of different organs

M. S. Wiesener, J. S. Jurgensen, +7 authors C. W. Pugh
FASEB J . • 2003
View 14 Excerpts
Highly Influenced

Modulation of mitochondrial function by hydrogen peroxide.

The Journal of biological chemistry • 2001
View 5 Excerpts
Highly Influenced

A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 2 Excerpts

VEGF: a critical player in neurodegeneration.

The Journal of clinical investigation • 2004
View 1 Excerpt

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