Cellular oxygen sensing need in CNS function: physiological and pathological implications.

  title={Cellular oxygen sensing need in CNS function: physiological and pathological implications.},
  author={Till Acker and Helmut Acker},
  journal={The Journal of experimental biology},
  volume={207 Pt 18},
Structural and functional integrity of brain function profoundly depends on a regular oxygen and glucose supply. Any disturbance of this supply becomes life threatening and may result in severe loss of brain function. In particular, reductions in oxygen availability (hypoxia) caused by systemic or local blood circulation irregularities cannot be tolerated for longer periods due to an insufficient energy supply to the brain by anaerobic glycolysis. Hypoxia has been implicated in central nervous… CONTINUE READING


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