Cellular oxygen sensing by mitochondria: old questions, new insight.

@article{Chandel2000CellularOS,
  title={Cellular oxygen sensing by mitochondria: old questions, new insight.},
  author={Navdeep S Chandel and Paul T Schumacker},
  journal={Journal of applied physiology},
  year={2000},
  volume={88 5},
  pages={1880-9}
}
Hypoxia elicits a variety of adaptive responses at the tissue level, at the cellular level, and at the molecular level. A physiological response to hypoxia requires the existence of an O(2) sensor coupled to a signal transduction system, which in turn activates the functional response. Although much has been learned about the signaling systems activated by hypoxia, no consensus exists regarding the nature of the underlying O(2) sensor or whether multiple sensors exist. Among previously… CONTINUE READING
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