Cellular oxygen sensing by mitochondria: old questions, new insight.

  title={Cellular oxygen sensing by mitochondria: old questions, new insight.},
  author={Navdeep S Chandel and Paul T Schumacker},
  journal={Journal of applied physiology},
  volume={88 5},
Hypoxia elicits a variety of adaptive responses at the tissue level, at the cellular level, and at the molecular level. A physiological response to hypoxia requires the existence of an O(2) sensor coupled to a signal transduction system, which in turn activates the functional response. Although much has been learned about the signaling systems activated by hypoxia, no consensus exists regarding the nature of the underlying O(2) sensor or whether multiple sensors exist. Among previously… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 150 extracted citations

Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K+ channels.

American journal of physiology. Lung cellular and molecular physiology • 2001
View 13 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 68 references

Oxygen dependence of mitochondrial function in isolated rat cardiac myocytes.

The American journal of physiology • 1986
View 4 Excerpts
Highly Influenced

Gradients of O2 concentration in hepatocytes.

The Journal of biological chemistry • 1978
View 4 Excerpts
Highly Influenced

Atmung bei sehr kleinen Sauerstoffdrucken

O Warburg, F. Kubowitz
Biochem Z 214: • 1929
View 4 Excerpts
Highly Influenced

Activation of flavin-containing oxidases underlies light-induced production of H2O2 in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 2 Excerpts

Similar Papers

Loading similar papers…