Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).

@article{McDonough2006CellularOS,
  title={Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).},
  author={Michael A McDonough and Vivian Pei-Hsin Li and Emily Flashman and Rasheduzzaman Chowdhury and Christopher R Mohr and Benoit M. R. Lienard and James Zondlo and Neil J Oldham and Ian J. Clifton and Jeffrey P Lewis and Luke A. McNeill and Robert J. M. Kurzeja and Kirsty S. Hewitson and Evelyn P Yang and Steven Jordan and Rashid S. Syed and Christopher J. Schofield},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 26},
  pages={9814-9}
}
Cellular and physiological responses to changes in dioxygen levels in metazoans are mediated via the posttranslational oxidation of hypoxia-inducible transcription factor (HIF). Hydroxylation of conserved prolyl residues in the HIF-alpha subunit, catalyzed by HIF prolyl-hydroxylases (PHDs), signals for its proteasomal degradation. The requirement of the PHDs for dioxygen links changes in dioxygen levels with the transcriptional regulation of the gene array that enables the cellular response to… CONTINUE READING

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