Cellular origins of fibroblasts: possible implications for organ fibrosis in systemic sclerosis.

@article{Postlethwaite2004CellularOO,
  title={Cellular origins of fibroblasts: possible implications for organ fibrosis in systemic sclerosis.},
  author={Arnold E. Postlethwaite and Hidenobu Shigemitsu and Siva Kanangat},
  journal={Current opinion in rheumatology},
  year={2004},
  volume={16 6},
  pages={733-8}
}
PURPOSE OF REVIEW There is an intense interest in the potential of circulating blood cells and epithelium-related nonfibroblast cells to change into matrix synthesizing fibroblasts and myofibroblasts. These sources of fibroblasts may have importance in systemic sclerosis (scleroderma). RECENT FINDINGS Epithelial cells from different sources can transition into fibroblasts and myofibroblasts in response to transforming growth factor beta and other growth factors/cytokines. This is called… CONTINUE READING

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