Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro.

@article{Drejer1985CellularOO,
  title={Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro.},
  author={Jrargen Drejer and Helene Benveniste and Nils Henrik Diemer and Arne Schousboe},
  journal={Journal of neurochemistry},
  year={1985},
  volume={45 1},
  pages={145-51}
}
The uptake and release of D-[3H]aspartate (used as a tracer for endogenous glutamate and aspartate) were studied in cultured glutamatergic neurons (cerebellar granule cells) and astrocytes at normal (5 mM) or high (55 mM) potassium and under conditions of hypoglycemia, anoxia or "ischemia" (combined hypoglycemia and anoxia). In glutamatergic neurons it was found that "ischemic" conditions led to a 2.4-fold increase in the potassium-induced release of D-[3H]aspartate as compared to normal… CONTINUE READING