Cellular micromotion monitored by long-range surface plasmon resonance with optical fluctuation analysis.

@article{Yang2015CellularMM,
  title={Cellular micromotion monitored by long-range surface plasmon resonance with optical fluctuation analysis.},
  author={Chih-Tsung Yang and R{\'e}gis M{\'e}jard and H Griesser and Pierre O. Bagnaninchi and Benjamin Thierry},
  journal={Analytical chemistry},
  year={2015},
  volume={87 3},
  pages={
          1456-61
        }
}
Long-range surface plasmon resonance (LRSPR) is a powerful biosensing technology due to a substantially larger probing depth into the medium and sensitivity, compared with conventional SPR. We demonstrate here that LRSPR can provide sensitive noninvasive measurement of the dynamic fluctuation of adherent cells, often referred to as the cellular micromotion. Proof of concept was achieved using confluent layers of 3T3 fibroblast cells and MDA-MB-231 cancer cells. The slope of the power spectral… CONTINUE READING
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