Cellular membrane phospholipids act as a depository for quaternary amine containing drugs thus competing with the acetylcholine/nicotinic receptor.

Abstract

We previously demonstrated that ammonium- or guanidinium-phosphate interactions are key to forming noncovalent complexes (NCXs) through salt bridge formation with G-protein coupled receptors (GPCR), which are immersed in the cell membrane's lipids. The present work highlights MALDI ion mobility coupled to orthogonal time-of-flight mass spectrometry (MALDI… (More)
DOI: 10.1021/pr300184g

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Cite this paper

@article{Barbacci2012CellularMP, title={Cellular membrane phospholipids act as a depository for quaternary amine containing drugs thus competing with the acetylcholine/nicotinic receptor.}, author={Damon C Barbacci and Shelley N. Jackson and Ludovic Muller and Thomas Egan and Ernest K Lewis and J. Albert Schultz and Amina S Woods}, journal={Journal of proteome research}, year={2012}, volume={11 6}, pages={3382-9} }