Cellular mechanisms underlying spontaneous firing in rat suprachiasmatic nucleus: involvement of a slowly inactivating component of sodium current.

@article{Pennartz1997CellularMU,
  title={Cellular mechanisms underlying spontaneous firing in rat suprachiasmatic nucleus: involvement of a slowly inactivating component of sodium current.},
  author={Cyriel M. A. Pennartz and M A Bierlaagh and Alwin M. S. Geurtsen},
  journal={Journal of neurophysiology},
  year={1997},
  volume={78 4},
  pages={1811-25}
}
Neurons constituting the pacemaker of circadian rhythms, located in the suprachiasmatic nucleus, generate spontaneous firing patterns that change across the day-night cycle. Their average spontaneous firing rate is considered an important functional marker of clock activity because it is highest during daytime and low at night. In this study we investigate the ionic mechanisms underlying spontaneous firing in acutely prepared slices and dissociated neurons of the suprachiasmatic nucleus. In… CONTINUE READING
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