Cellular mechanisms of prostaglandin action.

  title={Cellular mechanisms of prostaglandin action.},
  author={Russell Harris and Peter W. Ramwell and P J Gilmer},
  journal={Annual review of physiology},
The human platelet and erythrocyte differ quite dramatically in relation to the arachidonic acid cascade. The platelet synthesizes its own characteristic products, while the erythrocyte lacks cyclo-oxygenase activity but possesses other metabolic enzymes. In these and other cell types the metabolites are potentially determined by the cascade enzymes, the availability of cofactors, the presence of specific activators and inhibitors, and the selective binding or transport of intermediates… CONTINUE READING