Cellular mechanisms of neuroinflammatory pain: the role of interleukin-1beta.

  title={Cellular mechanisms of neuroinflammatory pain: the role of interleukin-1beta.},
  author={Chun-Sung Sung and C S Wong},
  journal={Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists},
  volume={45 2},
Dorsal horn of the spinal cord is important in the transduction and modulation of various pain signals. Interleukin-1beta (IL-1beta) not only plays an important role in the nociceptive modulation but also enhances the spinal cord nociceptive neuron wind-up. Intrathecal (i.t.) administration of IL-1beta activates p38 mitogen-activated protein kinase (MAPK), and leads to induction of inducible nitric oxide synthase (iNOS) and release of nitric oxide (NO), which sensitizes the spinal nociceptors… CONTINUE READING


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