Cellular mechanisms of bone repair.

  title={Cellular mechanisms of bone repair.},
  author={Axel Probst and H. U. Spiegel},
  journal={Journal of investigative surgery : the official journal of the Academy of Surgical Research},
  volume={10 3},
The extent of callus formation about a bone fracture depends on the rigidity of fracture fixation. The mechanism that converts the mechanical stimulus into the biologic response is unknown. On the basis of existing literature, an attempt has been made to define a model that explains this mechanobiologic transduction. Once integrity of the bone has been disrupted, a sequence of biochemical and cellular events commences that induces inflammatory reactions. Messengers (e.g., metabolites of the… CONTINUE READING