Cellular mechanisms of aortic valve calcification.

  title={Cellular mechanisms of aortic valve calcification.},
  author={Jane A. Leopold},
  journal={Circulation. Cardiovascular interventions},
  volume={5 4},
605 T he earliest description of calcific aortic stenosis is attributed to the French physician Lazare Rivière who, in 1663, reported the necropsy findings from a patient with palpitations , progressive dyspnea, and loss of peripheral pulses. He noted left ventricular enlargement and identified large car-uncle-like masses obstructing the left ventricular outflow to the aorta. 1 Although other reports followed, the debate about the etiology of aortic valve calcification (AVC) did not begin until… CONTINUE READING
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