Cellular mechanisms of IL-17-induced blood-brain barrier disruption.

  title={Cellular mechanisms of IL-17-induced blood-brain barrier disruption.},
  author={Jula Huppert and Dorothea Closhen and Andrew L Croxford and Robin White and Paulina Kulig and Eweline Pietrowski and Ingo Bechmann and Burkhard Becher and Heiko J. Luhmann and Ari Waisman and Christoph Ruediger Wolfram Kuhlmann},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={24 4},
Recently T-helper 17 (Th17) cells were demonstrated to disrupt the blood-brain barrier (BBB) by the action of IL-17A. The aim of the present study was to examine the mechanisms that underlie IL-17A-induced BBB breakdown. Barrier integrity was analyzed in the murine brain endothelial cell line bEnd.3 by measuring the electrical resistance values using electrical call impedance sensing technology. Furthermore, in-cell Western blots, fluorescence imaging, and monocyte adhesion and transendothelial… CONTINUE READING
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