Cellular mechanisms controlling caspase activation and function.

  title={Cellular mechanisms controlling caspase activation and function.},
  author={Amanda B. Parrish and Christopher D. Freel and Sally Kornbluth},
  journal={Cold Spring Harbor perspectives in biology},
  volume={5 6}
Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors, caspases are activated in response to a variety of cell death stimuli. In addition to factors required for their direct activation (e.g., dimerizing adaptor proteins in the case of initiator caspases that lie at the apex of apoptotic signaling cascades), caspases are regulated by a variety of cellular… CONTINUE READING
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