Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reaction in situ hybridization and immunohistochemistry.

@article{Wesselingh1997CellularLO,
  title={Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reaction in situ hybridization and immunohistochemistry.},
  author={Steve Lodewijk Wesselingh and Kazuya Takahashi and Jonathan D. Glass and Justin C. Mcarthur and John Wesley Griffin and Diane E Griffin},
  journal={Journal of neuroimmunology},
  year={1997},
  volume={74 1-2},
  pages={1-8}
}
HIV-induced neurological disease is postulated to be caused by indirect mechanisms. Tumor necrosis factor (TNF)alpha is increased in the brains in human immunodeficiency virus (HIV)-associated dementia and in the spinal cord in vacuolar myelopathy and may play a pathogenetic role in these diseases. Microglia, astrocytes and infiltrating macrophages can be induced to produce TNF alpha and each has been identified as a source of TNF alpha in neurological disease. Reverse transcriptase synthesis… CONTINUE READING