Cellular localization of the inhibitory action of abruquinone A against respiratory burst in rat neutrophils.

@article{Hsu1997CellularLO,
  title={Cellular localization of the inhibitory action of abruquinone A against respiratory burst in rat neutrophils.},
  author={M F Hsu and Shue Ling Raung and L. T. Tsao and Sheng Chu Kuo and Jih Pyang Wang},
  journal={British journal of pharmacology},
  year={1997},
  volume={120 5},
  pages={917-25}
}
1. The possible mechanisms of action of the inhibitory effect of abruquinone A on the respiratory burst in rat neutrophils in vitro was investigated. 2. Abruquinone A caused an irreversible and a concentration-dependent inhibition of formylmethionylleucyl-phenylalanine (fMLP) plus dihydrocytochalasin B (CB)- and phorbol 12-myristate 13-acetate (PMA)-induced superoxide anion (O2.-) generation with IC50 values of 0.33 +/- 0.05 microgram ml-1 and 0.49 +/- 0.04 microgram ml-1, respectively. 3… CONTINUE READING