Cellular localization of the K+ -dependent Na+ -Ca2+ exchanger NCKX5 and the role of the cytoplasmic loop in its distribution in pigmented cells.

@article{Rogasevskaia2019CellularLO,
  title={Cellular localization of the K+ -dependent Na+ -Ca2+ exchanger NCKX5 and the role of the cytoplasmic loop in its distribution in pigmented cells.},
  author={Tatiana P Rogasevskaia and Robert T. Szerencsei and R T Szerencsei and Frank C. Visser and Robert J. Winkfein and Paul P M Schnetkamp},
  journal={Pigment cell & melanoma research},
  year={2019},
  volume={32 1},
  pages={
          55-67
        }
}
NCKX5 is a bidirectional K+ -dependent Na+ -Ca2+ exchanger, which belongs to the SLC24A gene family. In particular, the A111T mutation of NCKX5 has been associated with reduced pigmentation in European populations. In contrast to other NCKX isoforms, which function in the plasma membrane (PM), NCKX5 has been shown to localize either in the trans-Golgi network (TGN) or in melanosomes. Moreover, sequences responsible for retaining its intracellular localization are unknown. This study addresses… CONTINUE READING
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