Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer

@article{Arina2007CellularLO,
  title={Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer},
  author={Ainhoa Arina and Oihana Murillo and Juan Dubrot and Arantza Azpilikueta and Carlos Alfaro and Jos{\'e} Luis P{\'e}rez-Gracia and Maurizio Bendandi and Bel{\'e}n Palencia and Sandra Herv{\'a}s-Stubbs and Ignacio Melero},
  journal={Expert Opinion on Biological Therapy},
  year={2007},
  volume={7},
  pages={599 - 615}
}
There is compelling evidence for the role of natural killer (NK) cells in tumor immunosurveillance and their beneficial effects on many experimentally successful immunotherapy strategies. NK cells mediate cell contact-dependent cellular cytotoxicity and produce pro-inflammatory cytokines, but do not rearrange antigen receptors. Their activation depends on various germline-encoded receptors, including CD16, which mediates recognition of antibody-coated target cells. NK cytotoxicity is checked by… 
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References

SHOWING 1-10 OF 144 REFERENCES
NK cell receptors as tools in cancer immunotherapy.
Natural killer cells and cancer.
Human natural killer cell development and biology.
Natural killer–dendritic cell cross-talk in cancer immunotherapy
TLDR
Compared with the standard mature DCs that are used in clinical trials at present, human NK cell-induced DC1s act as superior inducers of anticancer CTL responses during in vitro sensitisation, providing a strong rationale for the combined use of NK cells and DCs in the immunotherapy of patients with cancer and patients with chronic infections that are resistant to standard forms of treatment.
The role of natural killer cells in tumor control—effectors and regulators of adaptive immunity
TLDR
This review discusses NK cell function, the role of NK cells in cancer therapies, the emerging concept of bi-directional cross-talk between NK cells and dendritic cells, and the implications of these interactions for tumor immunotherapy.
Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
TLDR
It is demonstrated that ectopic expression of the murine NKG2D ligands Rae1β or H60 in several tumour cell lines results in potent rejection of the tumour cells by syngeneic mice.
A novel dendritic cell subset involved in tumor immunosurveillance
TLDR
Adoptive transfer of these IFN-producing killer dendritic cells into tumor-bearing Rag2/−Il2rg−/− mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not and was identified as pivotal sensors and effectors of the innate antitumor immune response.
Killer immunoglobulin-like receptors.
Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
TLDR
The data suggest that NK cell antitumor function can be enhanced greatly by strategies that are designed to expand and differentiate NK cells via DC activation of NKT cells.
Role of human natural killer cells in health and disease
TLDR
The therapeutic use of biologic response modifiers capable of augmenting NK cell activity in vivo and of adoptive transfer of highly enriched, activated autologous NK cells in diseases such as cancer and AIDS is being evaluated.
...
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3
4
5
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