Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer

@article{Arina2007CellularLO,
  title={Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer},
  author={Ainhoa Arina and Oihana Murillo and Juan Dubrot and Arantza Azpilikueta and Carlos Alfaro and Jos{\'e} Luis P{\'e}rez-Gracia and Maurizio Bendandi and Bel{\'e}n Palencia and Sandra Herv{\'a}s-Stubbs and Ignacio Melero},
  journal={Expert Opinion on Biological Therapy},
  year={2007},
  volume={7},
  pages={599 - 615}
}
There is compelling evidence for the role of natural killer (NK) cells in tumor immunosurveillance and their beneficial effects on many experimentally successful immunotherapy strategies. NK cells mediate cell contact-dependent cellular cytotoxicity and produce pro-inflammatory cytokines, but do not rearrange antigen receptors. Their activation depends on various germline-encoded receptors, including CD16, which mediates recognition of antibody-coated target cells. NK cytotoxicity is checked by… 
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