• DOI:10.1517/14712598.7.5.599
Corpus ID: 43003664

Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer

@article{Arina2007CellularLO,
  title={Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer},
  author={A. Arina and O. Murillo and Juan Dubrot and A. Azpilikueta and C. Alfaro and J. P{\'e}rez-Gracia and M. Bendandi and B. Palencia and S. Herv{\'a}s-Stubbs and I. Melero},
  journal={Expert Opinion on Biological Therapy},
  year={2007},
  volume={7},
  pages={599 - 615}
}

A. Arina, O. Murillo, +7 authors I. Melero

Published 2007

Biology, Medicine

Expert Opinion on Biological Therapy

There is compelling evidence for the role of natural killer (NK) cells in tumor immunosurveillance and their beneficial effects on many experimentally successful immunotherapy strategies. NK cells mediate cell contact-dependent cellular cytotoxicity and produce pro-inflammatory cytokines, but do not rearrange antigen receptors. Their activation depends on various germline-encoded receptors, including CD16, which mediates recognition of antibody-coated target cells. NK cytotoxicity is checked by… CONTINUE READING

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