Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer

  title={Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer},
  author={A. Arina and O. Murillo and Juan Dubrot and A. Azpilikueta and C. Alfaro and J. P{\'e}rez-Gracia and M. Bendandi and B. Palencia and S. Herv{\'a}s-Stubbs and I. Melero},
  journal={Expert Opinion on Biological Therapy},
  pages={599 - 615}
  • A. Arina, O. Murillo, +7 authors I. Melero
  • Published 2007
  • Biology, Medicine
  • Expert Opinion on Biological Therapy
  • There is compelling evidence for the role of natural killer (NK) cells in tumor immunosurveillance and their beneficial effects on many experimentally successful immunotherapy strategies. NK cells mediate cell contact-dependent cellular cytotoxicity and produce pro-inflammatory cytokines, but do not rearrange antigen receptors. Their activation depends on various germline-encoded receptors, including CD16, which mediates recognition of antibody-coated target cells. NK cytotoxicity is checked by… CONTINUE READING
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