Cellular levels of thymosin immunoreactive peptides are linked to proliferative events: evidence for a nuclear site of action.

@article{Conteas1990CellularLO,
  title={Cellular levels of thymosin immunoreactive peptides are linked to proliferative events: evidence for a nuclear site of action.},
  author={C. N. Conteas and M G Mutchnick and Kristine Palmer and Frederick E. Weller and Gordon D. Luk and Paul H. Naylor and Michael R Erdos and Allan L. Goldstein and Chinnakkannu Panneerselvam and Bernard L. Horecker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 9},
  pages={3269-73}
}
Thymosin alpha 1 (T alpha 1), the N-terminal 28-amino acid fragment of prothymosin alpha (ProT alpha), and ProT alpha, although originally isolated from whole thymus extracts, are also present in nonthymic cells and tissues. We used an ELISA with an antibody raised against T alpha 1 to investigate the relationship between intracellular levels of thymosin immunoreactive peptide(s) (TIP) and cell proliferation in a rat small intestinal IEC-6 cell line. Increasing TIP levels were observed during… CONTINUE READING

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