Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells

  title={Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells},
  author={Kanyan Xiao and David F. Allison and K. Buckley and Margaret D. Kottke and P. Vincent and V. Faundez and A. Kowalczyk},
  journal={The Journal of Cell Biology},
  pages={535 - 545}
The mechanisms by which catenins regulate cadherin function are not fully understood, and the precise function of p120 catenin (p120ctn) has remained particularly elusive. In microvascular endothelial cells, p120ctn colocalized extensively with cell surface VE-cadherin, but failed to colocalize with VE-cadherin that had entered intracellular degradative compartments. To test the possibility that p120ctn binding to VE-cadherin regulates VE-cadherin internalization, a series of approaches were… Expand
Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation.
p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin.
p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanism.
Unraveling the distinct distributions of VE- and N-cadherins in endothelial cells: a key role for p120-catenin.
N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis
N-Cadherin Levels in Endothelial Cells Are Regulated by Monolayer Maturity and p120 Availability
VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function.
Inducible expression of p120Cas1B isoform corroborates the role for p120-catenin as a positive regulator of E-cadherin function in intestinal cancer cells.
Role of p120-catenin in cadherin trafficking.


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Cadherin function in junctional complex rearrangement and posttranslational control of cadherin expression.
Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta-catenin.
Catenin-dependent and -independent Functions of Vascular Endothelial Cadherin (*)
  • P. Navarro, Luis Caveda, Ferruccio Breviario, Ileana Mândoteanu, Maria-Grazia Lampugnani, Elisabetta Dejana
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1995
A novel role for p120 catenin in E-cadherin function
Binding site for p120/δ-catenin is not required for Drosophila E-cadherin function in vivo
p120ctn Acts as an Inhibitory Regulator of Cadherin Function in Colon Carcinoma Cells
The Armadillo Family Protein p0071 Is a VE-cadherin- and Desmoplakin-binding Protein*
Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component
Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus