Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells

@article{Xiao2003CellularLO,
  title={Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells},
  author={Kanyan Xiao and David F. Allison and K. Buckley and Margaret D. Kottke and P. Vincent and V. Faundez and A. Kowalczyk},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={163},
  pages={535 - 545}
}
The mechanisms by which catenins regulate cadherin function are not fully understood, and the precise function of p120 catenin (p120ctn) has remained particularly elusive. In microvascular endothelial cells, p120ctn colocalized extensively with cell surface VE-cadherin, but failed to colocalize with VE-cadherin that had entered intracellular degradative compartments. To test the possibility that p120ctn binding to VE-cadherin regulates VE-cadherin internalization, a series of approaches were… Expand
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VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function.
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