Cellular ions in hypertension, diabetes, and obesity. A nuclear magnetic resonance spectroscopic study.

@article{Resnick1991CellularII,
  title={Cellular ions in hypertension, diabetes, and obesity. A nuclear magnetic resonance spectroscopic study.},
  author={Lawrence M. Resnick and Raj Kishore Gupta and Kuldeep K. Bhargava and H L Gruenspan and Michael H. Alderman and John H. Laragh},
  journal={Hypertension},
  year={1991},
  volume={17 6 Pt 2},
  pages={951-7}
}
To investigate the cellular basis linking hypertension, non-insulin-dependent diabetes mellitus (NIDDM), and obesity, we used 31P and 19F nuclear magnetic resonance spectroscopy to measure intracellular pH (pHi), free magnesium (Mgi), and cytosolic free calcium (Cai) in erythrocytes of obese and NIDDM subjects with and without hypertension. Compared with normotensive, nondiabetic controls (Cai, 25.2 +/- 1.4 nM; Mgi, 232 +/- 8 microM), Cai was elevated in both normotensive (36.8 +/- 2.7 nM, sig… CONTINUE READING