Cellular innate immunity and restriction of viral infection: implications for lentiviral gene therapy in human hematopoietic cells.

Abstract

Hematopoietic gene therapy has tremendous potential to treat human disease. Nevertheless, for gene therapy to be efficacious, effective gene transfer into target cells must be reached without inducing detrimental effects on their biological properties. This remains a great challenge for the field as high vector doses and prolonged ex vivo culture conditions… (More)
DOI: 10.1089/hum.2015.036

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