Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism.

@article{Cowan2002CellularIW,
  title={Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism.},
  author={Simone Cowan and Theodora Hatziioannou and Tshaka J Cunningham and Mark A. Muesing and Heinrich G. Gőttlinger and Paul D Bieniasz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 18},
  pages={11914-9}
}
Many nonhuman primate cells are unable to support the replication of HIV-1, whereas others are nonpermissive for infection by simian immunodeficiency virus from macaques (SIVmac). Here, we show that restricted HIV-1 and SIVmac infection of primate cell lines shares some salient features with Fv1 and Ref1-mediated restriction of murine retrovirus infection. In particular, the nonpermissive phenotype is most evident at low multiplicities of infection, results in reduced accumulation of reverse… CONTINUE READING
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