Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.

  title={Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.},
  author={Hal P. Bogerd and Heather L. Wiegand and Amy E. Hulme and Jose Luis Garc{\'i}a-P{\'e}rez and Kathy Sue O'Shea and John V Moran and Bryan R Cullen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 23},
Long interspersed element (LINE) 1 retrotransposons are major genomic parasites that represent approximately 17% of the human genome. The LINE-1 ORF2 protein is also responsible for the mobility of Alu elements, which constitute a further approximately 11% of genomic DNA. Representative members of each element class remain mobile, and deleterious retrotransposition events can induce spontaneous genetic diseases. Here, we demonstrate that APOBEC3A and APOBEC3B, two members of the APOBEC3 family… CONTINUE READING
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