Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

@article{Atkinson1994CellularIT,
  title={Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.},
  author={Mark A Atkinson and Mac A Bowman and Lisa Campbell and B L Darrow and Daniel L Kaufman and Noel K. Maclaren},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 5},
  pages={2125-9}
}
Insulin-dependent diabetes (IDD) results from the autoimmune destruction of the insulin-producing pancreatic beta cells. Autoreactive T-lymphocytes are thought to play a pivotal role in the pathogenesis of IDD; however, the target antigens of these cells, as well as the inductive events in the disease, are unclear. PBMC in persons with or at increased risk for IDD show elevated reactivity to the beta cell enzyme glutamate decarboxylase (GAD). To identify the T-lymphocyte-reactive determinants… CONTINUE READING

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