Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS,S/AS02, in semi-immune adults in The Gambia.

@article{Pinder2004CellularII,
  title={Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS,S/AS02, in semi-immune adults in The Gambia.},
  author={Margaret Pinder and William H. H. Reece and Magdalena Plebanski and Peter O Akinwunmi and Katie L Flanagan and Edwin A. M. Lee and Tom Doherty and Paul Milligan and Assan Jaye and Nadia Tornieporth and Rafik Ballou and Kenneth McAdam and Jonathan Cohen and Adrian V S Hill},
  journal={Clinical and experimental immunology},
  year={2004},
  volume={135 2},
  pages={286-93}
}
Vaccination of malaria-naive humans with recombinant RTS,S/AS02, which includes the C-terminus of the circumsporozoite protein (CS), has been shown to induce strong T cell responses to both the whole protein antigen and to peptides from CS. Here we show that strong T cell responses were also observed in a semi-immune population in The Gambia, West Africa. In a Phase I study, 20 adult male volunteers, lifelong residents in a malaria-endemic region, were given three doses of RTS,S/AS02 at 0, 1… CONTINUE READING

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