Cell culture are obtained from the saccular part of the kidney of Biomphalaria glabrata in a medium derived from Schneider drosophilia medium. Two types of cells migrate from the explant: numerous amoebocytes and some fibroblasts. Migration of amoebocytes appears to be regular. These amoebocytes are able to encapsulate and destroy particules and dead miracidiums. Amoebocytes from incompatible snails rapidly surround miracidiums and early larvae (primary sporocysts) whereas compatible miracidiums develop without amoebocyte reaction.