Cellular immune response to diverse islet cell antigens in IDDM.

@article{DurinovicBell1996CellularIR,
  title={Cellular immune response to diverse islet cell antigens in IDDM.},
  author={Ivana Durinovic-Bell{\'o} and Michael Hummel and Anette-G. Ziegler},
  journal={Diabetes},
  year={1996},
  volume={45 6},
  pages={795-800}
}
In IDDM, T-cells are postulated to mediate the destruction of pancreatic beta-cells. We analyzed peripheral blood mononuclear cell (PBMC) responses to human insulin, glutamate decarboxylase GAD65, tyrosine phosphatase ICA512, glucagon, membrane preparations of RIN cells and human pancreas, and three control antigens (La = nuclear cell antigen, tetanus toxoid, and phytohemagglutinin). A total of 28 patients with newly diagnosed IDDM, 9 antibody-positive (Ab+) first-degree relatives, and 16… CONTINUE READING