Cellular hydration state: an important determinant of protein catabolism in health and disease

@article{Hussinger1993CellularHS,
  title={Cellular hydration state: an important determinant of protein catabolism in health and disease},
  author={Daniel H{\"a}ussinger and Wolfgang Gerok and Evelyn Roth and François Lang},
  journal={The Lancet},
  year={1993},
  volume={341},
  pages={1330-1332}
}
There is evidence that cellular hydration state is an important factor controlling cellular protein turnover; protein synthesis and protein degradation are affected in opposite directions by cell swelling and shrinking. An increase in cellular hydration (swelling) acts as an anabolic proliferative signal, whereas cell shrinkage is catabolic and antiproliferative. The cellular hydration state is mainly determined by the activity of ion and substrate transport systems in the plasma membrane… CONTINUE READING

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