Cellular heterogeneity and molecular evolution in cancer.

  title={Cellular heterogeneity and molecular evolution in cancer.},
  author={Vanessa Almendro and Andriy Marusyk and Korn{\'e}lia Poly{\'a}k},
  journal={Annual review of pathology},
Intratumor heterogeneity represents a major obstacle to effective cancer treatment and personalized medicine. However, investigators are now elucidating intratumor heterogeneity at the single-cell level due to improvements in technologies. Better understanding of the composition of tumors, and monitoring changes in cell populations during disease progression and treatment, will improve cancer diagnosis and therapeutic design. Measurements of intratumor heterogeneity may also be used as… CONTINUE READING