Cellular growth inhibition by IGFBP‐3 and TGF‐β1 requires LRP‐1

@article{Huang2003CellularGI,
  title={Cellular growth inhibition by IGFBP‐3 and TGF‐$\beta$1 requires LRP‐1},
  author={Shuan Shian Huang and Thai-Yen Ling and Wen-Fang Tseng and Yen-Hwa Huang and Fen-Mei Tang and Sandra M Leal and Jung San Huang},
  journal={The FASEB Journal},
  year={2003},
  volume={17},
  pages={2068 - 2081}
}
The type V TGF‐β receptor (TβR‐V)/IGFBP‐3 receptor mediates the IGF‐independent growth inhibition induced by IGFBP‐3. It also mediates the growth inhibitory response to TGF‐β1 in concert with other TGF‐β receptor types, and its loss may contribute to the malignant phenotype of human carcinoma cells. Here we demonstrate that TβR‐V is identical to LRP‐1/α2M receptor as shown by MALDI‐TOF analysis of tryptic peptides of TβR‐V purified from bovine liver. In addition, 125I‐IGFBP‐3 affinity‐labeled T… 
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    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
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