Cellular glutathione content, in vitro chemoresponse, and the effect of BSO modulation in samples derived from patients with advanced ovarian cancer.

@article{Lewandowicz2002CellularGC,
  title={Cellular glutathione content, in vitro chemoresponse, and the effect of BSO modulation in samples derived from patients with advanced ovarian cancer.},
  author={Grazyna M Lewandowicz and Paul Britt and Alena W Elgie and Christine J Williamson and Helen M. Coley and Andrew G Hall and Jean M Sargent},
  journal={Gynecologic oncology},
  year={2002},
  volume={85 2},
  pages={298-304}
}
OBJECTIVES The objective was to assess the relationship between glutathione content and drug sensitivity with glutathione modulation in ovarian cancer in a pilot study using 31 samples of freshly obtained ovarian tumor material from 26 patients with advanced disease. METHODS Processed tumor samples were screened to determine the glutathione content using an enzyme recycling assay modified for use in a 96-well plate format. Chemosensitivity testing (MTT assay) was used to assess sensitivity to… CONTINUE READING

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