Cellular functions regulated by Src family kinases.

  title={Cellular functions regulated by Src family kinases.},
  author={S. M. Thomas and Joan S. Brugge},
  journal={Annual review of cell and developmental biology},
Src family protein tyrosine kinases are activated following engagement of many different classes of cellular receptors and participate in signaling pathways that control a diverse spectrum of receptor-induced biological activities. While several of these kinases have evolved to play distinct roles in specific receptor pathways, there is considerable redundancy in the functions of these kinases, both with respect to the receptor pathways that activate these kinases and the downstream effectors… 

Src family kinases, key regulators of signal transduction

This volume has attempted to provide the reader with an overview of the current understanding of the function of Src family kinases in the regulation of selected cellular signaling pathways.

The interplay between Src family kinases and receptor tyrosine kinases

Src family tyrosine kinases are involved in a diverse array of physiological processes, including participation in signaling pathways required for DNA synthesis, control of receptor turnover, actin cytoskeleton rearrangements and motility, and survival are discussed.

Novel regulation and function of Src tyrosine kinase

  • Y.-C. MaX. Huang
  • Biology, Chemistry
    Cellular and Molecular Life Sciences CMLS
  • 2002
This novel regulation of Src tyrosine kinase by G proteins provides insights into the adenylyl cyclase-independent signaling mechanisms involved in ligand-induced receptor desensitization, internalization and other physiological processes.

Coupling kinase activation to substrate recognition in SRC-family tyrosine kinases.

Src provides an example of the dramatic cellular consequences arising from the loss of autoregulation, and the relationship between the viral, oncogenic form of Src and the corresponding cellular proto-oncogene (c-Src) highlights the importance of inhibitory intramolecular interactions.

SRC family kinases in cell volume regulation.

  • D. Cohen
  • Biology
    American journal of physiology. Cell physiology
  • 2005
Mounting evidence suggests a broad role for SRC family kinases in the cell response to both hypertonic and hypotonic stress, and in the ensuing regulatory volume increase or decrease, as well as in the mechanotransduction that accompanies cell membrane deformation.

Ubiquitin-mediated degradation of active Src tyrosine kinase.

Results establish ubiquitin-mediated proteolysis as a previously unidentified mechanism for irreversibly attenuating the effects of active Src kinase.

Recent advances in the discovery of Src kinase inhibitors

A number of examples of currently developed Src family kinase inhibitors in selected patents from 2002 – 2005 will be described, with special attention made to the chemical diversity of ATP binding site inhibitors, potency, selectivity and therapeutic application of the compounds.

Src Family of Protein Tyrosine Kinases


Src family protein tyrosine kinases and cellular signal transduction pathways.

Regulation, substrates and functions of src.

Receptor tyrosine kinases and their targets.

  • A. Kazlauskas
  • Biology, Computer Science
    Current opinion in genetics & development
  • 1994

Cytokine signaling through nonreceptor protein tyrosine kinases.

The intracytoplasmic structure of cytokine receptors has evolved so as to allow the combined action of different PTK family members expressed in different cell types, which may ultimately determine the activity of cytokines.

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

The activated BTK was predominantly membrane-associated, which suggests that BTK integrates distinct receptor signals resulting in SRC kinase activation and BTK membrane targeting.

Multiple kinases mediate T-cell-receptor signaling.

Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor

Gβγ subunit-mediated activation of Src family nonreceptor tyrosine kinases can account for the Gi-coupled receptor-mediated tyrosinesine phosphorylation events that direct recruitment of the Shc and Grb2 adapter proteins to the membrane.

Signaling through the hematopoietic cytokine receptors.

Hematopoiesis is regulated through the interaction of a variety of growth factors with specific receptors of the cytokine receptor superfamily through a novel family of protein tyrosine kinases termed the Janus kinases (Jaks).