Cellular functions of the amyloid precursor protein from development to dementia.

@article{Kant2015CellularFO,
  title={Cellular functions of the amyloid precursor protein from development to dementia.},
  author={Rik van der Kant and Lawrence S. B. Goldstein},
  journal={Developmental cell},
  year={2015},
  volume={32 4},
  pages={502-15}
}
Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD). The Aβ fragments of APP are the major constituent of AD-associated amyloid plaques, and mutations or duplications of the gene coding for APP can cause familial AD. Here we review the roles of APP in neuronal development, signaling, intracellular transport, and other aspects of neuronal homeostasis. We suggest that APP acts as a signaling nexus that transduces information about a range of extracellular conditions… CONTINUE READING
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