Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis.

@article{Bourdeau2009CellularFA,
  title={Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis.},
  author={Raymond W. Bourdeau and Enrico Malito and Alexandre Chenal and Brian L Bishop and Mark W Musch and Mitch L Villereal and Eugene B Chang and Elise M Mosser and Richard F. Rest and W Tang},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 21},
  pages={14645-56}
}
Anthrolysin O (ALO) is a pore-forming, cholesterol-dependent cytolysin (CDC) secreted by Bacillus anthracis, the etiologic agent for anthrax. Growing evidence suggests the involvement of ALO in anthrax pathogenesis. Here, we show that the apical application of ALO decreases the barrier function of human polarized epithelial cells as well as increases intracellular calcium and the internalization of the tight junction protein occludin. Using pharmacological agents, we also found that barrier… CONTINUE READING

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