Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders

@inproceedings{Veen2014CellularFA,
  title={Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders},
  author={Sarah van Veen and Danny Mollerup S\orensen and Tine Holemans and Henrik Waldal Holen and Michael Palmgren and Peter Vangheluwe},
  booktitle={Front. Mol. Neurosci.},
  year={2014}
}
Mutations in ATP13A2 lead to Kufor-Rakeb syndrome, a parkinsonism with dementia. ATP13A2 belongs to the P-type transport ATPases, a large family of primary active transporters that exert vital cellular functions. However, the cellular function and transported substrate of ATP13A2 remain unknown. To discuss the role of ATP13A2 in neurodegeneration, we first provide a short description of the architecture and transport mechanism of P-type transport ATPases. Then, we briefly highlight key P-type… CONTINUE READING