Cellular forms and functions of brain microglia

@article{Davis1994CellularFA,
  title={Cellular forms and functions of brain microglia},
  author={Elizabeth Davis and Thomas D. Foster and W. Eric Thomas},
  journal={Brain Research Bulletin},
  year={1994},
  volume={34},
  pages={73-78}
}
Consistent with the recent characterization of microglial cells as macrophages, an overall picture for the unique function of these cells in CNS tissue has developed. The microglia are derived from blood monocytes that migrate into the tissue during fetal development and subsequently remain after complete formation of the blood-brain barrier. These monocytes give rise to the ramified microglia of adult tissue through the developmental intermediate of amoeboid microglia. Ramified microglia… Expand
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References

SHOWING 1-10 OF 63 REFERENCES
Functional plasticity of microglia: A review
TLDR
A role of CNS microglia as a source of defense cells in the CNS capable of carrying out certain immune functions autonomously is supported, which may lead to a redefinition of the often cited “immune privilege” of the brain. Expand
Characterisation of ramified microglial cells: detailed morphology, morphological plasticity and proliferative capability.
TLDR
It was concluded that ramified microglia definitely possess proliferative capability, and this may reduce the need for blood cell recruitment in brain immune responses and provide an amenable preparation for investigating the regulation of microglial function. Expand
Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
TLDR
The results provide strong support for the hypothesis that the microglia are derived from monocytes and show thatmicroglia possess receptors which would allow them to play a part in the immune defence of the nervous system. Expand
Characterization of ameboid microglia isolated from developing mammalian brain
  • D. Giulian, T. J. Baker
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1986
TLDR
It is suggested that in vitro ameboid microglia differentiate into nonphagocytic cells similar to ramifiedmicroglia found in normal adult brain. Expand
Brain macrophages: questions of origin and interrelationship.
TLDR
The idea is presented that the most likely source for all or most brain macrophages is monocytic blood cells, which may continue to enter, at least from blood vessels, in the adult state. Expand
New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury
TLDR
Following lethal motor neuron injury microglia and perivascular cells, as well as brain macrophages derived from the latter two cell types, newly express antigens of the myelomonocytic lineage as recognized by the monoclonal antibodies ED1 and ED3. Expand
Microglia in human disease, with an emphasis on acquired immune deficiency syndrome.
TLDR
There is overwhelming evidence that within the CNS the primary sites of active HIV-1 infection are microglia and Cytokines appear to be prime candidates as mediators of some of the adverse effects of microglial infection on other CNS cells, myelin and endothelial cells. Expand
The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain
TLDR
The observations show that mononuclear phagocytes play a major role in wound healing after CNS trauma with some events controlled by secretion of cytokines, and certain classes of immunosuppressive drugs may be useful in the treatment of acute brain injury. Expand
Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells
TLDR
Microglial cells isolated from brain cell cultures of newborn mice were characterized and investigated for morphology, their responses to growth factors and their functional properties, and taken together they share the characteristics of cells of the macrophage lineage. Expand
Vault immunofluorescence in the brain: new insights regarding the origin of microglia
TLDR
Vault immunoreactivity, as a very early microglial marker, provides new insight regarding the much-debated origin of the ramified microglia, and colocalization studies with monocyte/macrophage markers ED1 and OX42 demonstrate that both ramified and ameboidmicroglia originate from monocyte lineage. Expand
...
1
2
3
4
5
...