Cellular factors modulating the mechanism of tau protein aggregation

  title={Cellular factors modulating the mechanism of tau protein aggregation},
  author={Sarah N. Fontaine and Jonathan J. Sabbagh and Jeremy D. Baker and Carlos R. Martinez-Licha and April L. Darling and Chad A Dickey},
  journal={Cellular and Molecular Life Sciences},
Pathological accumulation of the microtubule-associated protein tau, in the form of neurofibrillary tangles, is a major hallmark of Alzheimer’s disease, the most prevalent neurodegenerative condition worldwide. In addition to Alzheimer’s disease, a number of neurodegenerative diseases, called tauopathies, are characterized by the accumulation of aggregated tau in a variety of brain regions. While tau normally plays an important role in stabilizing the microtubule network of the cytoskeleton… CONTINUE READING
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