Cellular expression of plasma prekallikrein in human tissues.

  title={Cellular expression of plasma prekallikrein in human tissues.},
  author={Edwin Fink and Kanti D. Bhoola and Celia Snyman and Peter Neth and Carlos D. Figueroa},
  journal={Biological chemistry},
  volume={388 9},
Plasma prekallikrein (PPK) is synthesised in hepatocytes and secreted into the blood, where it participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. Recently we demonstrated by quantitative RT-PCR that the human PPK gene is transcribed not only in the liver, but also in various non-hepatic human tissues at significant levels. However, up to now no reliable information is available concerning protein synthesis in the corresponding… CONTINUE READING


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