Cellular expression of green fluorescent protein, coupled with high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis.

@article{Naumov1999CellularEO,
  title={Cellular expression of green fluorescent protein, coupled with high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis.},
  author={George N. Naumov and Shannon M Wilson and I C Macdonald and Eric E. Schmidt and Vincent L. Morris and Alan C. Groom and Robert M Hoffman and Ann F. Chambers},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 12)},
  pages={1835-42}
}
High resolution intravital videomicroscopy has provided a powerful tool for directly observing steps in the metastatic process, and for clarifying molecular mechanisms of metastasis and modes of action of anti-metastasis therapeutics. Cells previously have been identified in vivo using exogenously added fluorescent labels, limiting observations to a few cell divisions, or by natural markers (e.g. melanin) expressed only by specific cell types. Here we tested the utility of stable green… CONTINUE READING
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In vivo videomicroscopy of experimental hematogenous metastasis: cancer cell arrest, extravasation and migration

  • I. C. MacDonald, E. E. Schmidt, V. L. Morris, A. C. Groom, A. F. Chambers
  • Motion Analysis of Living Cells (ed. D. R. Soll…
  • 1998
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