Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand

@article{Huard2004CellularEA,
  title={Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand},
  author={Bertrand Huard and Philippe Gaulard and Florence Faure and Thierry Hercend and Frederic Triebel},
  journal={Immunogenetics},
  year={2004},
  volume={39},
  pages={213-217}
}
The lymphocyte activation gene 3 (LAG-3), expressed in human activated T and natural killer (NK) cells, is closely related to CD4 at the gene and protein levels (Triebel et al. 1990). The characterization of genomic clones encompassing the LAG-3 locus revealed that the position of the introns in the LAG-3 structure is very close to that of CD4 and that both genes include an intron within the first immunoglobulin superfamily (IgSF) domain. In addition, both genes are located on the distal part… Expand
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