Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.

@article{Moosmang2001CellularEA,
  title={Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.},
  author={S. Moosmang and J. Stieber and X. Zong and M. Biel and F. Hofmann and A. Ludwig},
  journal={European journal of biochemistry},
  year={2001},
  volume={268 6},
  pages={
          1646-52
        }
}
Hyperpolarization-activated cation currents (I(h)) have been identified in cardiac pacemaker cells and a variety of central and peripheral neurons. Four members of a gene family encoding hyperpolarization-activated, cyclic nucleotide-gated cation channels (HCN1--4) have been cloned recently. Native I(h) currents recorded from different cell types exhibit distinct activation kinetics. To determine if this diversity of I(h) currents may be caused by differential expression of HCN channel isoforms… Expand
Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes
TLDR
The aim of this study is to examine the age-related Ih and HCN channels subunits in different ages and sizes of dorsal root ganglion (DRG) neurons in different age periods and to understand the physiological and pathophysiological function of different sizes of DRG neurons inDifferent age periods. Expand
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TLDR
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TLDR
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TLDR
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TLDR
The results suggest that HCN4 may be a unique marker of the developing SA node in postnatal and adult heart, and the site of HCN 4 expression in late embryonic heart coincided with the location of the SA node. Expand
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TLDR
Recent insights into the structure, function, and cellular regulation of HCN channels are summarized and evidence on the role of individual HCN channel types arising from the analysis ofHCN knockout mouse models is discussed. Expand
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TLDR
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TLDR
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Cardiac HCN channels: structure, function, and modulation.
The hyperpolarization-activated cation current (termed I(f), I(h), or I(q)) plays a key role in the initiation and modulation of cardiac and neuronal pacemaker depolarizations. Recently, theExpand
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TLDR
It is found that Ih activity is not essential for the transduction of cold stimuli in CS neurons, Nevertheless, Ih has the potential to shape the excitability of CS neurons. Expand
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TLDR
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TLDR
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