Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis.

@article{Tome1997CellularEI,
  title={Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis.},
  author={Margaret E Tome and Eugene W. Gerner},
  journal={Biological signals},
  year={1997},
  volume={6 3},
  pages={150-6}
}
The polyamines are essential for eukaryotic cell growth. One of the most critical effects of polyamines on cell growth is the availability of spermidine for the post-translational modification of eIF-5A. Because hypusine-containing eIF-5A is necessary for cell proliferation, depletion of cellular polyamines suppresses growth by depleting cellular modified eIF-5A content. Excess putrescine accumulations in DH23A/b cells induces apoptosis and suppresses the formation of hypusine-containing eIF-5A… CONTINUE READING

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